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J Pharm Sci 93:1537–1544 [DOI] [PubMed] [Google Scholar] Ebens A, Brose K, Leonardo ED, Hanson MG, Jr, Bladt F, Birchmeier C, Barres BA, Tessier-Lavigne M

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1 Introduction Acute Mountain Sickness (AMS) is a common and potentially debilitating condition that affects individuals ascending to altitudes above 2,500 m above sea level (Araneda et al., 2005), resulting from a decrease in the partial pressure of gases, particularly oxygen (O 2 ), a condition known as hypobaric hypoxia (Bailey and Davies, 2001)