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BH4 availability is largely driven by the Mg 2+ , Zn 2+ , and NADPH dependent de novo synthesis pathway composed of the rate limiting enzyme GTP cyclohydrolase I (GCH1) together with 6-pyruvoyl-tetrahydropterin synthase and sepiapterin reductase

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Chronic intermittent hypoxia sensitizes acute hypothalamic-pituitary-adrenal stress reactivity and Fos induction in the rat locus coeruleus in response to subsequent immobilization stress