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For further studies, we utilised Gpx4 flox/wt ;Villin-Cre +/− ( Gpx4 +/−IEC ) mice 27,28 , which specifically deleted one Gpx4 allele in the intestinal epithelium and resulted in a ~50% reduction of mRNA and protein levels in small and large intestinal IECs (Supplementary Fig
C10H17N3O6S Molecular Weight
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