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Model building, refinement, and validation Model buildings of both c-MET/HGF and c-MET/NK1 complexes were initiated by rigid-body docking of individual domains from the crystal structures of SEMA, PSI, IPT1, and IPT2 domains of c-MET and N, K1, K2, and SPH domains of HGF 14,24,25,30

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The mechanistic complementarity (rather than competition) of their hepatic roles