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Mechanistic plausibility does not equal proven clinical efficacy at any specific dose

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6a) shows subsurface trend maxima of 0.08–0.1 psu per 70 years centered at 200–300 m depth near 30° N and 30° S, with negative trends present across the upper water column in the tropics with no clear surface intensification, consistent with the competing effects of freshening and subduction in this region