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FOXO4-DRI is a D-amino acid retro-inverso peptide designed to disrupt the interaction between the FOXO4 transcription factor and p53 inside senescent cells

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141,142 Recurrent somatic mutation of residues are mainly located at enzymatic active sites that bind to isocitrate, typically at R132 including R132H, R132L, R132S, R132C, and R132G in IDH1, and R140Q or R172K in IDH2