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In fact, sotatercept (ACE-011), an ACVR2A fusion protein originally designed by Acceleron Pharma to increase bone mineral density 123 , unexpectedly promoted rapid increases in hematocrit, hemoglobin, red blood cells, and late-stage erythropoiesis, which were suggested to be caused by suppression of endogenous GDF11 124 , although recent studies using conditional knockout techniques refuted this mechanism 125,126

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Degraded peptide delivers inconsistent dosing that undermines study reproducibility