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Blood Sugar and Diabetes Chlorogenic acids have several proposed mechanisms for glucose regulation: inhibition of alpha-glucosidase (IC50: 27.14 mcg/ml) and alpha-amylase (IC50: 21.93 mcg/ml) to slow carbohydrate digestion, suppression of glucose-6-phosphatase activity, promotion of glucose uptake via upregulation of GLUT2 and GLUT4 transporters, and activation of AMP-activated protein kinase (AMPK) to enhance insulin sensitivity [5][6]