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A subset of clinical research has also demonstrated that adding B12 (and other B-vitamins) to existing antidepressant regimens can improve response rates compared to antidepressants alone, particularly when baseline B12 was suboptimal

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doi: 10.1111/j.1471-4159.2004.02914.x 70 CorkSCRichardsJEHoltMKGribbleFMReimannFTrappS

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