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Intranasal delivery of Huperzine A to the brain using lactoferrin-conjugated N-trimethylated chitosan surface-modified PLGA nanoparticles for treatment of Alzheimer’s disease

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In a human GBM xenograft model (MGG8), A2V did not substantially alter vascular morphometric parameters yet significantly prolonged survival through mechanisms independent of overt vascular remodeling, suggesting antitumor activity beyond vascular endpoints