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2.1 Decreased NAD + levels and MetS NAD + serves as a critical coenzyme in the conversion of carbohydrates into lipids and fuel oxidation (Belenky et al., 2007)

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Clinical trial data indicates tesofensine-induced weight loss consists predominantly of fat mass loss with notable preservation of lean body mass, a critical distinction from general caloric restriction which typically results in proportional loss of both fat and muscle tissue