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Three new #obesity drugs—high-dose semaglutide, semaglutide plus cagrilintide, and oral orforglipron—may soon be approved in the US. JAMA Medical News Director Jennifer Abbasi and Lead Senior Staff Writer Rita Rubin examine how

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Other gastrointestinal sensations include: Feeling of fullness or early satiety after eating smaller portions than usual Mild abdominal discomfort or bloating Diarrhea (reported in 12-22% of patients, dose-dependent) Constipation (7-17% of patients, dose-dependent) Vomiting (2-10% of patients) Dyspepsia or gastroesophageal reflux symptoms Decreased appetite (reported in up to 27% of patients) Appetite and eating pattern changes represent another prominent category of sensations