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However, it has also been shown that high concentrations of atomoxetine can induce oxidative stress and alter mitochondrial function in differentiated neuronal cells [54,236]

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However, when the level of APAP overwhelms the primary glucuronidation pathway, the GSH stores are consumed by a generation of the excess NAPQI metabolites and by the formation of mitochondrial NAPQI protein adducts, leading to hepatocellular injury [243]