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This contributes to $6 billion spent yearly on gallstone-related treatments
Cholesterol
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Darley–Usmar and coworkers have shown that HNE directly modifies Keap1, which allows Nrf2 to avoid degradation and migrate to the nucleus where it can bind to EpRE elements in the promoters of the human GCLC and GCLM genes (Levonen et al., 2004)
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