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Moreover, in macrophages, the pro-inflammatory M1 marker’s morphology and genes (associated with pro-inflammatory cytokine production) are suppressed by sulforaphane, while it promotes the M2 marker genes associated with the anti-inflammatory mechanism [73,77,85,99]

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However, while Tβ15 was found only up-regulated in different malignancies, such as the human prostate cancer, representing a potential biomarker (Bao et al., 1996), in a healthy human body only Tβ4 and Tβ10 are expressed (Huff et al., 2001)