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The enzyme is mainly located in the endoplasmic reticulum, uses UDP-glucuronic acid as the glucuronosyl donor, and is referred to as bilirubin-UGT

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The non-enzymatic form, although less important, comes from the reduction of elemental sulfur to H 2 S using reductants that come from glucose oxidation, such as lactate, or others such as nicotinamide adenine dinucleotide hydrogen (NADH), nicotinamide adenine dinucleotide phosphate (NADPH) and glutathione (Figure 3)