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10.3389/FNMOL.2019.00086/PDF [DOI] [PMC free article] [PubMed] [Google Scholar] Suh JH, Shenvi SV, Dixon BM et al (2004) Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid

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Lantus works over 24 hours, and GSH's effect on insulin sensitivity is not an acute spike but a chronic shift over days to weeks of supplementation [6]