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Metabolic and Lipolytic Signaling Pathways Beyond anabolic signaling, IGF-1 LR3’s receptor activation is linked to metabolic effects documented in research settings, including increased glucose uptake into muscle and adipose tissue via GLUT-4 transporter upregulation and enhanced amino acid transport that supports tissue repair processes

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Its neuroregulatory effects on the hypothalamus and GABAergic systems further contribute to improved overall sleep quality (2)