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Taken together, Lambert and colleagues concluded that acrolein and other 2-alkenals found in cigarette smoke can disrupt physiological regulation of gene expression by direct modification of the DNA-binding domain of a transcription factor and, as a consequence, they may cause immunosuppression upon exposure via cigarette smoke
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Second, all the methods that have been used, till now, to stimulate [Ca 2+ ] i elevation (such as drugs, uncaging of Ins(1,4,5)P 3 or Ca 2+ , and mechanical stimulation of Ca 2+ release) or to block intracellular Ca 2+ release (such as Ca 2+ buffering, TCA cycle inhibition, or tetanus neurotoxin) in astrocytes are non-specific and are not likely to occur in vivo or, at least, one cannot be sure that this released glutamate actually comes from astrocytes in vivo [7]
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