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Current treatment guidelines In patients with low-risk MDS, the primary treatment goal is to improve cytopenias, reduce transfusion dependency and improve quality of life, which is typically achieved through a “watch & wait” approach, supportive care with red blood count (RBC) or platelet transfusions, iron chelation and antibiotics

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In the first step of the pathway, the Glc-6-P dehydrogenase (G6PDH) reaction produces NADPH by oxidation of Glc-6-P to 6-phosphogluconic acid lactone, a cyclic sugar ester