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Extended high-frequency audiometry (9–20 kHz) may detect early basal cochlear damage before standard frequencies are affected, providing a critical window for intervention ( Historically proposed schedules include baseline assessment, weekly monitoring during treatment, and follow-up at 1, 3, and 6 months post-treatment to detect delayed-onset or progressive losses ( Vestibular function assessment is frequently overlooked, despite well-recognized vestibulotoxicity risk posed by aminoglycosides as a class

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Further, GSH can be regenerated by GR using nicotinamide adenine dinucleotide phosphate (NADPH) as the substrate (Fig