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3 Mammalian CHAC2: defining its role in glutathione homeostasis, cancer progression and stem cell fate In addition to CHAC1, which is found exclusively in higher eukaryotes, organisms from bacteria to mammals possess a CHAC2 enzyme that exhibits a highly similar glutathione-specific γGCT activity (Kaur et al., 2017)

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3.3 Application of network pharmacology in cancer drug target development NP, as an emerging research approach, has the advantage of considering multiple targets and signaling pathways simultaneously, which aligns with the complexity and heterogeneity of cancer